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Brainpeps®

Brainpeps® is a resource of blood-brain barrier properties of peptides. This database is managed by Ghent University. Based upon your input, this search page will give you all information (structure, method, responses, physicochemical properties and related literature). The database is linked to a manuscript entitled "Brainpeps: the blood-brain barrier peptide database", in which the BBB methods and responses are clarified and correlated to each other.

Reference:

Sequence, Trivial name, Molecular formula, Method, Response, Literature
Peptide
Sequence (1-letter or 3-letter code)
For the 1-letter and 3-letter sequences, the nomenclature recommended by the IUPAC-IUBMB Joint Commision on Biochemical Nomenclature is used: Nomenclature and Symbolism for Amino Acids and Peptides. The used nomenclature for unnatural amino acids can be found on the following link: Nomenclature unnatural Amino Acids.
, trivial name, abbreviation, molecular formula The molecular formula is entered using the following template, maintaining the order of the atoms: CxHxNxOxSxClx. If no S- or Cl-atoms are present, they don’t need to be filled in.
CYFQNCPRG
Cys-Tyr-Phe-Gin-Asn-Cys-Pro-Arg-Gly
Vasopressin
VP
C22H41N8O9S1 		Method List of available methods

(Co)-culture
Antinociception
BMEC
BUI method
Capillary depletion
Capillary depletion-in situ brain perfusion
Efflux study (ICV)
hCMEC/D3
HPLC
Imaging techniques
In situ brain perfusion
In situ brain perfusion (single time)
Intracarotid injection
Intraperitoneal injection
Intravenous injection
Intravenous injection (multiple time regression)
MS detection in acceptor compartment (hCMEC/D3)?
MS detection in brain?
PAMPA
Shake flask
Name
Intravenous injection 		Literature
Author
Title
Year
Journal (full)
Response List of available responses (parameter name)

% capillary
% injected dose
% parenchyma
Area
Blood/brain ratio
Brain to plasma ratio
Brain/perfusate ratio
BUI
Ccsf
CD (brain/serum)
CD (capillary/serum)
CD (parenchyma/serum)
CD(brain/perfusate)
CD(capillary/perfusate)
CD(parenchyma/perfusate)
ED50
Fold change vs control phage
ICV/SC ratio
ki
Kin,initial
Kin
kout
Log D
Log P
P
Papp
Pendoth
Pe
PI
PS
RBr
Rpellet
Rsupernatant
Radioactivity ratio
t1/2, brain
t1/2, serum
Translocated
VD
Vi
Yes
Name
Kin
Vi

Citation

If you are using or downloading data from the database, please cite "Van Dorpe S., Bronselaer A., Nielandt J., Stalmans S., Wynendaele E., Audenaert K., Van De Wiele C., Burvenich C., Peremans K., Hsuchou H., De Tré G. and De Spiegeleer B. Brainpeps: the blood-brain barrier peptide database. Brain Structure and Function, 2012, 217(3), 687-718, http://link.springer.com/article/10.1007%2Fs00429-011-0375-0”.

General Information

- Data submission to Brainpeps
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